Abstract
We examined the effect of 12 weeks of daily oral administration of pentoxifylline with zinc and folic acid on the semen quality of 36 men with varicocele-associated infertility in an open, uncontrolled study. After 4 weeks of treatment, the proportion of morphologically normal sperm cells was significantly increased; these changes persisted until at least 4 weeks after the end of treatment.
MeSH terms
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Adult
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Antioxidants / administration & dosage
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Antioxidants / pharmacology*
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Folic Acid / administration & dosage
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Folic Acid / pharmacology*
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / pharmacology*
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Humans
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Infertility, Male / drug therapy
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Infertility, Male / physiopathology
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Male
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Pentoxifylline / administration & dosage
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Pentoxifylline / pharmacology*
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Reproductive Techniques, Assisted
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Sperm Motility / drug effects*
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Sperm Motility / physiology
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Spermatozoa / drug effects*
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Spermatozoa / physiology
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Varicocele / drug therapy*
Substances
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Antioxidants
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Free Radical Scavengers
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Folic Acid
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Pentoxifylline