Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital

Cancer Lett. 1976 Sep;2(1):11-5. doi: 10.1016/s0304-3835(76)80004-3.

Abstract

Diethylnitrosamine (DENA) hepatocarcinogenesis was enhanced by sequential exposure with polychlorinated biphenyls (PCBs) and with phenobarbital. This was shown by the earlier appearance of tumors and a significant increase in the number of tumors. However, there was no evidence suggesting an acceleration of tumor growth.

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / chemically induced*
  • Carcinoma, Hepatocellular / pathology
  • Diethylnitrosamine / toxicity*
  • Drug Synergism
  • Liver Neoplasms / chemically induced*
  • Liver Neoplasms / pathology
  • Male
  • Neoplasms, Experimental / chemically induced
  • Neoplasms, Experimental / pathology
  • Nitrosamines / toxicity*
  • Phenobarbital / pharmacology*
  • Polychlorinated Biphenyls / pharmacology*
  • Rats
  • Time Factors

Substances

  • Nitrosamines
  • Diethylnitrosamine
  • Polychlorinated Biphenyls
  • Phenobarbital