Abstract
Diethylnitrosamine (DENA) hepatocarcinogenesis was enhanced by sequential exposure with polychlorinated biphenyls (PCBs) and with phenobarbital. This was shown by the earlier appearance of tumors and a significant increase in the number of tumors. However, there was no evidence suggesting an acceleration of tumor growth.
MeSH terms
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Animals
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Carcinoma, Hepatocellular / chemically induced*
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Carcinoma, Hepatocellular / pathology
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Diethylnitrosamine / toxicity*
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Drug Synergism
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Liver Neoplasms / chemically induced*
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Liver Neoplasms / pathology
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Male
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Neoplasms, Experimental / chemically induced
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Neoplasms, Experimental / pathology
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Nitrosamines / toxicity*
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Phenobarbital / pharmacology*
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Polychlorinated Biphenyls / pharmacology*
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Rats
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Time Factors
Substances
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Nitrosamines
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Diethylnitrosamine
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Polychlorinated Biphenyls
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Phenobarbital