Localization of Paxillin, a Focal Adhesion Protein, to Smooth Muscle Dense Plaques, and the Myotendinous and Neuromuscular Junctions of Skeletal Muscle

Exp Cell Res. 1991 Feb;192(2):651-5. doi: 10.1016/0014-4827(91)90090-h.

Abstract

In this report we have demonstrated that paxillin, a cytoskeletal protein which is present in focal adhesions, localizes in vivo to regions of cell-extracellular matrix interaction which are believed to be analogous to focal adhesions. Specifically, it is enriched in the dense plaques of chicken gizzard smooth muscle tissue and in the myotendinous junctions formed in Xenopus laevis tadpole tail skeletal muscle. In addition, paxillin was identified at the rat diaphragm neuromuscular junction. The distribution of paxillin is thus comparable to that of other focal adhesion proteins, for example, talin and vinculin, in these structures.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Cell Adhesion / physiology
  • Chickens
  • Cytoskeletal Proteins / analysis
  • Extracellular Matrix / metabolism
  • Membrane Proteins / analysis*
  • Muscle Proteins / analysis*
  • Muscle, Smooth / chemistry*
  • Muscles / chemistry*
  • Neuromuscular Junction / chemistry*
  • Talin
  • Tendons / chemistry
  • Xenopus laevis

Substances

  • Antibodies, Monoclonal
  • Cytoskeletal Proteins
  • Membrane Proteins
  • Muscle Proteins
  • Talin