Interleukin 10: a novel stimulatory factor for mast cells and their progenitors

J Exp Med. 1991 Feb 1;173(2):507-10. doi: 10.1084/jem.173.2.507.


We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division
  • Cell Line
  • Interleukin-10
  • Interleukin-3 / physiology
  • Interleukin-4 / physiology
  • Interleukins / physiology*
  • Mast Cells / cytology*
  • Mast Cells / ultrastructure
  • Mice
  • Mice, Inbred C57BL
  • Rats
  • Rats, Inbred Strains
  • Recombinant Proteins


  • Interleukin-3
  • Interleukins
  • Recombinant Proteins
  • Interleukin-10
  • Interleukin-4