Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in nonhuman primates

Am J Clin Nutr. 1991 Feb;53(2):491-8. doi: 10.1093/ajcn/53.2.491.

Abstract

Three species of monkey (rhesus, cebus, and squirrel) were rotated through five purified diets containing 31% energy as various fat blends (P:S between 0.1 and 1.0) for 12-wk periods to compare the impact of specific dietary fatty acids on plasma lipids and lipoproteins. As 12:0 + 14:0 was replaced by 16:0, a significant decrease occurred in total and LDL cholesterol, whereas slight increases in total cholesterol and the LDL-HDL ratio occurred when 16:0 replaced 18:2. Hegsted and Keys regression equations provided a good fit for the observed data, but the predicted total cholesterol response was perfect (r = 0.995) for both equations when 16:0 was considered neutral. Thus, under these conditions 16:0 was less cholesterolemic than 12:0 + 14:0 and only slightly cholesterolemic compared with 18:2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cebus
  • Cholesterol / blood*
  • Dietary Fats / pharmacology*
  • Fatty Acids / pharmacology*
  • Forecasting
  • Haplorhini / blood*
  • Lipoproteins / blood*
  • Macaca mulatta
  • Regression Analysis
  • Saimiri
  • Species Specificity

Substances

  • Dietary Fats
  • Fatty Acids
  • Lipoproteins
  • Cholesterol