Antioxidant therapy in Alzheimer's disease: theory and practice

Mini Rev Med Chem. 2008 Nov;8(13):1395-406. doi: 10.2174/138955708786369582.


Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Brain / pathology
  • Free Radical Scavengers / pharmacology
  • Free Radical Scavengers / therapeutic use
  • Humans
  • Oxidative Stress / drug effects


  • Antioxidants
  • Free Radical Scavengers