Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population

Ann N Y Acad Sci. 2008 Oct;1139:57-62. doi: 10.1196/annals.1432.021.

Abstract

Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine-Related Disorders / genetics*
  • Asian Continental Ancestry Group / genetics*
  • Calcineurin / genetics*
  • Case-Control Studies
  • Central Nervous System Stimulants / pharmacology*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Methamphetamine / pharmacology*
  • Polymorphism, Single Nucleotide
  • Psychoses, Substance-Induced / genetics*
  • Schizophrenia / genetics

Substances

  • Central Nervous System Stimulants
  • Methamphetamine
  • Calcineurin
  • PPP3CC protein, human