Do fatty acids help in overcoming reading difficulties? A double-blind, placebo-controlled study of the effects of eicosapentaenoic acid and carnosine supplementation on children with dyslexia

Child Care Health Dev. 2009 Jan;35(1):112-9. doi: 10.1111/j.1365-2214.2008.00881.x. Epub 2008 Oct 28.

Abstract

Background: There are claims that dietary supplementation of unsaturated fatty acids could help children with dyslexia to overcome their reading problems. However, these claims have not yet been empirically tested.

Methods: This study was designed to test whether dietary supplementation was superior to placebo in treating reading, spelling or other reading-related skills of children with dyslexia. The experimental group (eicosapentaenoic acid, EPA, n = 30) ate dietary supplements and the control group (placebo, n = 31) placebos during the 90-day treatment period. The supplements contained omega-3 fatty acid (ethyl-EPA, 500 mg/day) and carnosine (400 mg/day). The groups were matched for reading skills, grade, gender, attention problems, intelligence and amount of special education. The literacy-related skills of the two groups were assessed before and after the treatment period.

Results: No group differences were observed between EPA and placebo in measures of reading accuracy or speed, spelling, decoding fluency, arithmetical skills, reading-related language skills, attention or behavioural problems.

Conclusion: The present findings do not support the hypothesis that omega-3 fatty acid (ethyl-EPA) or carnosine has a role in the treatment of reading and spelling problems in children with dyslexia.

Publication types

  • Controlled Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carnosine / administration & dosage*
  • Case-Control Studies
  • Child
  • Combined Modality Therapy / methods
  • Dietary Supplements*
  • Double-Blind Method
  • Dyslexia / diet therapy*
  • Dyslexia / epidemiology
  • Eicosapentaenoic Acid / administration & dosage*
  • Female
  • Finland / epidemiology
  • Humans
  • Male
  • Treatment Outcome

Substances

  • Carnosine
  • Eicosapentaenoic Acid