Abstract
Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process intersects with cytokine-mediated antimicrobial responses.
MeSH terms
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Animals
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Autophagy*
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Autophagy-Related Protein 5
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Host-Pathogen Interactions
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Humans
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Listeria monocytogenes / physiology*
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Listeriosis / immunology*
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Listeriosis / microbiology
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Macrophages / immunology*
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Macrophages / parasitology
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Microtubule-Associated Proteins / genetics
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Microtubule-Associated Proteins / immunology*
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Toxoplasma / physiology*
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Toxoplasmosis / immunology*
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Toxoplasmosis / parasitology
Substances
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Atg5 protein, mouse
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Autophagy-Related Protein 5
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Microtubule-Associated Proteins