Digest this! A role for autophagy in controlling pathogens

Cell Host Microbe. 2008 Nov 13;4(5):413-4. doi: 10.1016/j.chom.2008.10.008.

Abstract

Autophagy provides a mechanism for cells to conserve nutrients, but was recently associated with immunity to intracellular pathogens. Here, Zhao et al. (2008) present direct in vivo evidence that autophagy is linked to macrophage control of Toxoplasma gondii and Listeria monocytogenes and highlights that this process intersects with cytokine-mediated antimicrobial responses.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy*
  • Autophagy-Related Protein 5
  • Host-Pathogen Interactions
  • Humans
  • Listeria monocytogenes / physiology*
  • Listeriosis / immunology*
  • Listeriosis / microbiology
  • Macrophages / immunology*
  • Macrophages / parasitology
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / immunology*
  • Toxoplasma / physiology*
  • Toxoplasmosis / immunology*
  • Toxoplasmosis / parasitology

Substances

  • Atg5 protein, mouse
  • Autophagy-Related Protein 5
  • Microtubule-Associated Proteins