Abstract
Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.
MeSH terms
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Animals
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Cattle
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DNA Polymerase I / antagonists & inhibitors
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DNA Polymerase beta / antagonists & inhibitors
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Rats
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Structure-Activity Relationship
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Terpenes / chemical synthesis*
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Terpenes / chemistry*
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Terpenes / pharmacology
Substances
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Enzyme Inhibitors
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Terpenes
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kohamaic acid A
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DNA Polymerase I
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DNA Polymerase beta