mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin

Biosci Biotechnol Biochem. 2008 Nov;72(11):3067-70. doi: 10.1271/bbb.80450. Epub 2008 Nov 7.


Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.

MeSH terms

  • Animals
  • Circadian Rhythm / genetics
  • Female
  • Gene Expression Regulation, Enzymologic*
  • Male
  • Matrix Metalloproteinase 12 / genetics*
  • Mice
  • Protein-Lysine 6-Oxidase / genetics*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sex Characteristics
  • Skin / metabolism*


  • RNA, Messenger
  • Protein-Lysine 6-Oxidase
  • Matrix Metalloproteinase 12