Effect of caffeine supplementation on repeated sprint running performance

J Sports Med Phys Fitness. 2008 Dec;48(4):472-8.


Aim: This study examined the effects of 6 mgxkg(-1) caffeine ingestion in team-sport players (N.=10) on repeated-sprint running performance (5 sets of 6 x 20 m) and reaction times, 60 min after caffeine or placebo ingestion.

Methods: Best single sprint and total set sprint times, blood lactate and simple and choice reaction times (RT) were measured.

Results: Total sprint times across sets 1, 3 and 5 (departure every 25 s) were significantly faster after caffeine (85.49+/-5.55 s) than placebo (86.98+/-5.78 s) (P<0.05). Similarly, total sprint times across sets 2 and 4 (departure every 60 s), were significantly faster after caffeine (55.99+/-3.64 s) than placebo (56.77+/-3.74 s) (P<0.05). Significantly higher blood lactates were recorded in caffeine compared to placebo after set 3 (13.1+/-1.2 vs 10.3+/-1.4 mmolxL(-1)) (P<0.05) and set 5 (13.1+/-1.3 vs 10.3+/-1.6 mmolxL(-1)) (P<0.01). There were no significant effects on simple or choice RT, although effect sizes suggested improved post-exercise times after caffeine.

Conclusion: Caffeine ingestion 60 min prior to exercise can enhance repeated sprint running performance and is not detrimental to reaction times.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Athletic Performance / physiology*
  • Caffeine / administration & dosage*
  • Central Nervous System Stimulants / administration & dosage*
  • Dose-Response Relationship, Drug
  • Humans
  • Lactic Acid / blood
  • Male
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism
  • Reaction Time / drug effects
  • Running / physiology*
  • Surveys and Questionnaires


  • Central Nervous System Stimulants
  • Lactic Acid
  • Caffeine