Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Nat Genet. 2008 Dec;40(12):1402-3. doi: 10.1038/ng.251. Epub 2008 Nov 9.

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Introns
  • Kinesin / genetics*
  • Multiple Sclerosis / genetics*

Substances

  • KIF1B protein, human
  • Kinesin