The oxygenation of cholesterol esters by the reticulocyte lipoxygenase

FEBS Lett. 1991 Feb 11;279(1):110-4. doi: 10.1016/0014-5793(91)80263-3.


The arachidonate 15-lipoxygenase from rabbit reticulocytes oxygenates cholesterol esters containing polyenoic fatty acids. Cholesterol esterified with saturated fatty acids is not oxygenated. The structures of the oxygenation products formed from various cholesterol esters have been identified by high pressure liquid chromatography, UV-spectroscopy and gas chromatography/mass spectroscopy. Oxygenated cholesterol esters have been detected in atherosclerotic plaques of human aortas.

MeSH terms

  • Arteriosclerosis / metabolism
  • Cholesterol Esters / isolation & purification
  • Cholesterol Esters / metabolism*
  • Chromatography, High Pressure Liquid
  • Humans
  • Lipoxygenase / metabolism*
  • Oxygen / metabolism*
  • Reticulocytes / enzymology*
  • Substrate Specificity


  • Cholesterol Esters
  • Lipoxygenase
  • Oxygen