MD Anderson Cancer Center strives to share data from its central tissue bank with other institutions via the caBIG data sharing framework. To conform to "NCI Best Practices for Biospecimen Resources", a caGRID compatible model (i.e. caTissue Core/Suite) must be adopted or an existing tissue banking application (TissueStation) must be adapted for interoperability. We present a data model assessment and method used in development of an enterprise strategy for ensuring inter-institution data sharing capabilities.