Polygenic model for predicting breast cancer risk via genome-wide polymorphisms

AMIA Annu Symp Proc. 2008 Nov 6:1094.

Abstract

A polygenic model for predicting susceptibility to late-onset, sporadic forms of breast-cancer based on an individual's SNP profile was developed. The model was validated using a publicly available data set with genome-wide SNP markers for cases and controls. Preliminary results show that this method performs better than expected by chance.

MeSH terms

  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / genetics*
  • Chromosome Mapping / methods*
  • Computer Simulation
  • Diagnosis, Computer-Assisted / methods
  • Female
  • Genetic Predisposition to Disease / epidemiology*
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing / methods
  • Humans
  • Models, Genetic*
  • Polymorphism, Single Nucleotide / genetics*
  • Proportional Hazards Models
  • Risk Assessment / methods
  • Risk Factors
  • Utah