Leukotriene inhibition in small animal medicine

J Vet Pharmacol Ther. 2008 Oct;31(5):387-98. doi: 10.1111/j.1365-2885.2008.00963.x.


Leukotrienes are important mediators of inflammatory and allergic conditions in people and are suspected to play an important role in tumorigenesis and tumor growth of several different tumor types. Based on this, researchers are making great progress in identifying novel pharmacologic targets for several human diseases. Leukotriene inhibition has resulted in therapeutic benefit in clinical trials involving people with osteoarthritis, allergic asthma, and atopic dermatitis. Despite this progress and the possibility that leukotriene inhibition may also play an important therapeutic role in veterinary patients, parallel advances have not yet been made in veterinary medicine. This article summarizes leukotriene function and synthesis. It also reviews the published literature regarding potential therapeutic applications of leukotriene inhibition in both human and veterinary medicine, focusing primarily on osteoarthritis, NSAID induced gastrointestinal mucosal damage, allergic asthma, atopic dermatitis, and cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Asthma / drug therapy
  • Asthma / etiology
  • Humans
  • Leukotriene Antagonists / pharmacology
  • Leukotriene Antagonists / therapeutic use*
  • Leukotrienes* / adverse effects
  • Leukotrienes* / biosynthesis
  • Leukotrienes* / physiology
  • Neoplasms / drug therapy
  • Neoplasms / etiology
  • Osteoarthritis / drug therapy
  • Pyrazoles / pharmacokinetics
  • Pyrazoles / pharmacology*
  • Receptors, Leukotriene* / drug effects
  • Receptors, Leukotriene* / physiology


  • Anti-Inflammatory Agents, Non-Steroidal
  • Leukotriene Antagonists
  • Leukotrienes
  • Pyrazoles
  • Receptors, Leukotriene
  • tepoxalin