Nutritional regulation of glucagon-like peptide-1 secretion

J Physiol. 2009 Jan 15;587(1):27-32. doi: 10.1113/jphysiol.2008.164012. Epub 2008 Nov 10.


Glucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP-1 or preventing its degradation, attention is now turning towards the L-cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP-1 in vivo. Understanding the mechanisms underlying GLP-1 release from L-cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L-cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L-cell nutrient responsiveness.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Eating / physiology
  • Enteroendocrine Cells / drug effects
  • Enteroendocrine Cells / metabolism
  • Enteroendocrine Cells / physiology
  • Glucagon-Like Peptide 1 / metabolism*
  • Glucose / administration & dosage
  • Glucose / metabolism
  • Glutamate Plasma Membrane Transport Proteins / metabolism
  • Humans
  • KATP Channels / metabolism
  • Models, Biological
  • Signal Transduction
  • Taste Buds / physiology


  • Glutamate Plasma Membrane Transport Proteins
  • KATP Channels
  • Glucagon-Like Peptide 1
  • Glucose