Signaling cross-talk between TGF-beta/BMP and other pathways

Cell Res. 2009 Jan;19(1):71-88. doi: 10.1038/cr.2008.302.

Abstract

Transforming growth factor-beta (TGF-beta)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-beta/BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-beta/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-beta/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bone Morphogenetic Proteins / physiology*
  • Humans
  • Intercellular Signaling Peptides and Proteins / physiology
  • MAP Kinase Signaling System
  • Receptor Cross-Talk*
  • Receptors, Transforming Growth Factor beta / physiology*
  • Signal Transduction*
  • Transcription Factors / physiology
  • Transforming Growth Factor beta / physiology*

Substances

  • Bone Morphogenetic Proteins
  • Intercellular Signaling Peptides and Proteins
  • Receptors, Transforming Growth Factor beta
  • Transcription Factors
  • Transforming Growth Factor beta