Bcl-3, a multifaceted modulator of NF-kappaB-mediated gene transcription

Immunol Res. 2008;42(1-3):210-8. doi: 10.1007/s12026-008-8075-4.


The transcription factor, NF-kappaB (nuclear factor-kappaB) and associated regulatory factors make up a multi-component signaling pathway that regulates a wide range of biological processes, including cell survival, proliferation, differentiation, stress response, and death, as well as immunity and inflammation. Aberrant NF-kappaB pathway activity is known to be associated with a host of diseases, including immune deficiencies, inflammatory disorders, and cancer. Recent advances in our understanding of the inner workings of the NF-kappaB pathway have led to the development of new therapeutic strategies for the treatment of these diseases. In this review, we focus on the regulation of the NF-kappaB pathway by Bcl-3 (B cell leukemia-3), a nuclear member of the IkappaB (inhibitor of NF-kappaB) family. Both the regulation and the function of Bcl-3 will be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Cell Lymphoma 3 Protein
  • Gene Expression Regulation*
  • Humans
  • NF-kappa B / physiology*
  • Protein Processing, Post-Translational
  • Proto-Oncogene Proteins / physiology*
  • RNA Stability
  • Transcription Factors / physiology*
  • Transcription, Genetic / genetics


  • B-Cell Lymphoma 3 Protein
  • BCL3 protein, human
  • NF-kappa B
  • Proto-Oncogene Proteins
  • Transcription Factors