Use of recombinant human interferon gamma to enhance neutrophil chemotactic responses in Job syndrome of hyperimmunoglobulinemia E and recurrent infections

J Pediatr. 1991 Mar;118(3):383-7. doi: 10.1016/s0022-3476(05)82151-1.

Abstract

Recombinant human interferon gamma enhances neutrophil respiratory burst and bactericidal activity in patients with chronic granulomatous disease. Mononuclear leukocytes of patients with the hyperimmunoglobulinemia E syndrome (Job syndrome) produce low or undetectable levels of this lymphokine. For these reasons we have restudied neutrophil chemotaxis in a group of our patients with the syndrome and determined the effect of recombinant human interferon gamma on the responses. Each of the patients had neutrophil chemotactic responses ranging from 22% to 55% of simultaneous control values (p less than 0.001). After incubation with interferon gamma, a significant improvement in chemotactic responsiveness was observed in the neutrophils of each of the patients (mean 301% of baseline chemotaxis; p less than 0.008). These data suggest the need for a double-blind, placebo-controlled trial of interferon gamma in a larger group of patients with the syndrome of hyperimmunoglobulinemia E and recurrent infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bacterial Infections / blood*
  • Bacterial Infections / physiopathology
  • Chemotaxis, Leukocyte / physiology*
  • Child, Preschool
  • Humans
  • Hypergammaglobulinemia / blood*
  • Hypergammaglobulinemia / physiopathology
  • Immunoglobulin A / analysis
  • Immunoglobulin E* / analysis
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Interferon-gamma / pharmacology*
  • Job Syndrome / blood*
  • Job Syndrome / physiopathology
  • Neutrophils / physiology*
  • Recombinant Proteins
  • Recurrence

Substances

  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Recombinant Proteins
  • Immunoglobulin E
  • Interferon-gamma