An overview of viral and viral-like agents in cell culture systems

Cytotechnology. 1998 Nov;28(1-3):49-52. doi: 10.1023/A:1008061110314.


The first recognition of seriously contaminated biological products occurred almost 100 years ago. More recently, in the second half of this century, the potential for contamination by viral and viral-like agents became obvious when the SV-40 virus was identified as an endogenous agent in the cell cultures used to produce polio vaccines. The history of major contamination incidents is reviewed, and current issues are discussed.