Objective: To assess the effects of feminine hygiene wet wipes on vulvar skin.
Study design: An examiner-blind, randomized, prospective clinical trial of prototype wet wipes (treatment group) and dry toilet tissue (comparison group) in 120 premenopausal and 60 postmenopausal women was conducted in which the wipes or toilet tissues were for approximately 28 consecutive days.
Results: Use of wet wipes in lieu of toilet tissue caused no significant impact on erythema of the external genitalia. Mean vulvar erythema scores after 28 days of product use were lower than baseline scores for both wipes and toilet tissue. In postmenopausal women, wet wipes were associated with increased labial and perineal skin moisture. A minority of premenopausal participants found skin wetness from wipes less appealing and sometimes associated with slight sensory irritation; however, wet wipes were favored for personal cleansing by postmenopausal women.
Conclusion: Four weeks of using wet wipes caused negligible clinical effects on vulvar skin irritation and appeared to contribute to skin moisture in postmenopausal women. This subgroup preferred using wet wipes, possibly due to the skin atrophy and dryness that accompany estrogen depletion. An opportunity exists to tailor the lotion level on the wipes m to the genital skin condition and preferences of younger and older Women.