Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production

J Theor Biol. 2009 Jun 7;258(3):455-64. doi: 10.1016/j.jtbi.2008.09.037. Epub 2008 Oct 19.


Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / biosynthesis*
  • Adenosine Triphosphate / metabolism
  • Animals
  • Citric Acid Cycle / physiology*
  • Computer Simulation*
  • Energy Metabolism
  • Humans
  • Mitochondria / metabolism*
  • Models, Biological
  • Oxygen Consumption


  • Adenosine Triphosphate