Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats

J Gen Virol. 2008 Dec;89(Pt 12):3173-3176. doi: 10.1099/vir.0.2008/004150-0.


Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie in sheep, with the alleles AHQ and AF141RQ strongly associated with occurrence of the disease. The presence of histidine at codon 154 has also been detected in Nor98-affected goats, but statistical analysis of the association between Nor98 and goat PRNP polymorphisms has not been reported previously. Here, a case-control study was carried out on eight Nor98-positive goats and 246 negative herdmates belonging to eight Italian Nor98 scrapie outbreaks. The results revealed that histidine at codon 154 is also strongly associated with the disease in goats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Case-Control Studies
  • Codon / genetics*
  • Genetic Predisposition to Disease
  • Genotype
  • Goat Diseases / genetics*
  • Goats
  • Histidine / genetics*
  • Mutation
  • Polymorphism, Genetic*
  • Prions / genetics*
  • Risk Factors
  • Scrapie / genetics*


  • Codon
  • Prions
  • Histidine