A low dimensional description of globally coupled heterogeneous neural networks of excitatory and inhibitory neurons

PLoS Comput Biol. 2008 Nov;4(11):e1000219. doi: 10.1371/journal.pcbi.1000219. Epub 2008 Nov 14.


Neural networks consisting of globally coupled excitatory and inhibitory nonidentical neurons may exhibit a complex dynamic behavior including synchronization, multiclustered solutions in phase space, and oscillator death. We investigate the conditions under which these behaviors occur in a multidimensional parametric space defined by the connectivity strengths and dispersion of the neuronal membrane excitability. Using mode decomposition techniques, we further derive analytically a low dimensional description of the neural population dynamics and show that the various dynamic behaviors of the entire network can be well reproduced by this reduced system. Examples of networks of FitzHugh-Nagumo and Hindmarsh-Rose neurons are discussed in detail.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology
  • Models, Neurological
  • Nerve Net*
  • Neurons*