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, 14 (11-12), 741-51

Adipokines and Insulin Resistance


Adipokines and Insulin Resistance

Katja Rabe et al. Mol Med.


Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system--thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-alpha and interleukin-6, vaspin, and visfatin on insulin resistance.


Figure 1
Figure 1
Obesity, adipokines and insulin resistance. Murine resistin is expressed in white adipose tissue, whereas in humans, resistin is mainly produced by peripheral-blood mononuclear cells. Green arrows depict stimulation, red lines suppression of gene expression.

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