Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides

Je Won Park; Hong-Se Oh; Won Seok Jung; Sung Ryeol Park; Ah Reum Han; Yeon-Hee Ban; Eun Ji Kim; Han-Young Kang; Yeo Joon Yoon

doi:10.1039/b814603a

Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides

Chem Commun (Camb). 2008 Nov 30:(44):5782-4. doi: 10.1039/b814603a. Epub 2008 Oct 1.

Authors

Je Won Park¹, Hong-Se Oh, Won Seok Jung, Sung Ryeol Park, Ah Reum Han, Yeon-Hee Ban, Eun Ji Kim, Han-Young Kang, Yeo Joon Yoon

Affiliation

¹ Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.

PMID: 19009080
DOI: 10.1039/b814603a

Abstract

An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / biosynthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Disk Diffusion Antimicrobial Tests
Macrolides / chemistry
Macrolides / metabolism*
Macrolides / pharmacology
Multigene Family
Streptomyces / genetics
Streptomyces / metabolism*

Substances

Anti-Bacterial Agents
Macrolides