Sinonasal malignancies of neuroendocrine origin

Hematol Oncol Clin North Am. 2008 Dec;22(6):1297-316, xi. doi: 10.1016/j.hoc.2008.08.008.


The sinonasal malignancies of putative neuroendocrine origin-esthesioneuroblastoma, sinonasal neuroendocrine carcinoma, sinonasal undifferentiated carcinoma, and sinonasal small cell carcinoma-are uncommon malignancies that frequently present with locally advanced disease. Pathologic distinction between these entities can be difficult, but is important to guide management. These malignancies require complex multimodality treatment and are best managed by multidisciplinary teams in major centers that have expertise in sinonasal malignancies.

Publication types

  • Review

MeSH terms

  • Combined Modality Therapy / methods
  • Humans
  • Neuroendocrine Tumors / pathology*
  • Neuroendocrine Tumors / therapy*
  • Nose Neoplasms / pathology*
  • Nose Neoplasms / therapy*