Bupropion attenuates methamphetamine self-administration in adult male rats

Drug Alcohol Depend. 2009 Feb 1;100(1-2):54-62. doi: 10.1016/j.drugalcdep.2008.09.006. Epub 2008 Nov 17.

Abstract

Bupropion is a promising candidate medication for methamphetamine use disorder. As such, we used a preclinical model of drug-taking to determine the effects of bupropion on the reinforcing effects of methamphetamine (0.025, 0.05 or 0.1 mg/kg/infusion). Specificity was determined by investigating the effects of bupropion on responding maintained by sucrose. In the self-administration study, rats were surgically prepared with indwelling jugular catheters and trained to self-administer methamphetamine under an FR5 schedule. A separate group of rats was trained to press a lever for sucrose. Once responding stabilized, rats were pretreated with bupropion (0, 10, 30 and 60 mg/kg i.p.) 5 min before chamber placement in a unique testing order. Following acute testing, rats were then repeatedly pretreated with 30 and 60 mg/kg bupropion. Acute treatments of bupropion dose dependently reduced drug intake for 0.025-0.1 mg/kg methamphetamine; sucrose deliveries were only reduced with the high bupropion dose. Repeated exposure to 60 mg/kg bupropion before the session resulted in a consistent decrease in methamphetamine intake (0.05 and 0.1 mg/kg) and sucrose deliveries. Considered together, this pattern of findings demonstrates that bupropion decreases responding for methamphetamine, but the effects are only somewhat specific.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine-Related Disorders / prevention & control*
  • Amphetamine-Related Disorders / psychology
  • Animals
  • Behavior, Addictive / prevention & control
  • Behavior, Addictive / psychology
  • Bupropion / therapeutic use*
  • Dose-Response Relationship, Drug
  • Male
  • Methamphetamine / administration & dosage*
  • Rats
  • Rats, Sprague-Dawley
  • Self Administration

Substances

  • Bupropion
  • Methamphetamine