Anaplastic oligodendroglioma after childhood acute lymphoblastic leukemia: chemotherapy and autologous peripheral blood stem cell transplantation

J Pediatr Hematol Oncol. 2008 Oct;30(10):764-7. doi: 10.1097/MPH.0b013e31817e4a55.


Secondary brain tumors after cranial irradiation occur in survivors of childhood acute lymphoblastic leukemia (ALL). We report a case of anaplastic oligodendroglioma with recurrence occurring in a 15-year-old girl, 8 years after the diagnosis of ALL. She was treated with cisplatin, vincristine, etoposide, and ifosfamide followed by cranial irradiation with good response. However, as new lesions appeared out of the radiation field and then multiple lesions after she stopped the chemotherapy, she was treated with procarbazine, CCNU, and vincristine followed by autologous peripheral blood stem cell transplantation with preconditioning of carboplatin, thiotepa, and etoposide. She showed no evidence of disease for 3 years after last recurrence. High-dose chemotherapy with stem cell rescue seems to be potentially effective for multiple recurrent anaplastic oligodendroglioma occurring after childhood ALL.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cranial Irradiation
  • Disease-Free Survival
  • Female
  • Humans
  • Neoplasms, Second Primary / therapy*
  • Oligodendroglioma / etiology
  • Oligodendroglioma / therapy*
  • Peripheral Blood Stem Cell Transplantation
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Recurrence