Meningitis caused by lymphocytic choriomeningitis virus in a patient with leukemia

J Pediatr Hematol Oncol. 2008 Oct;30(10):781-4. doi: 10.1097/MPH.0b013e318182e72b.


We report a case of 15-year-old girl with T-cell acute lymphoblastic leukemia who had fever, neutropenia, and severe headache while receiving maintenance chemotherapy. Cerebrospinal fluid testing revealed a lymphocytic pleocytosis and no evidence of relapsed leukemia. Meningitis caused by lymphocytic choriomeningitis virus was identified serologically. The patient's course was complicated by hydrocephalus requiring ventriculoperitoneal shunt placement and by an intracranial hemorrhage. Lymphocytic choriomeningitis virus is a rare cause of aseptic meningitis that should be considered in the symptomatic immunocompromised patient with an appropriate exposure history.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Female
  • Humans
  • Hydrocephalus / etiology
  • Immunocompromised Host
  • Intracranial Hemorrhages / etiology
  • Lymphocytic Choriomeningitis / etiology*
  • Lymphocytic Choriomeningitis / virology
  • Lymphocytic choriomeningitis virus / isolation & purification*
  • Meningitis, Aseptic / etiology*
  • Meningitis, Aseptic / virology
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Serologic Tests