[Project REMISSION(PLUS): clinical and radiological remission : new treatment goals in the management of rheumatoid arthritis]

Z Rheumatol. 2008 Dec;67(8):707-10, 712-5. doi: 10.1007/s00393-008-0369-3.
[Article in German]


In a large number of patients with rheumatoid arthritis (RA), chronic inflammatory processes cause joint changes and loss of function even in the early stages of disease. Early, targeted use of disease-modifying antirheumatic drugs [DMARDs and TNF-alpha blockers ("biologicals")] can significantly reduce the risk of aggressive progression and irreversible joint damage. Hence, early identification of disease-specific processes of joint inflammation and erosion - at the onset of disease or later - is of key importance for the patient's prognosis and therapeutic strategy. This can be achieved today with great precision and reliability through the use of modern imaging methods like arthrosonography and magnetic resonance imaging (MRI). The REMISSION(PLUS) initiative aspire to integrate modern imaging technologies as standard methods in the care and management of RA patients. The main areas on which this initiative will be focusing are the conceptualization and implementation of educational programs and training seminars on sonography and MRI, the development and establishment of case report forms for standardized documentation of findings, and the systematic monitoring of patients on treatment, with the aim of producing very precise documentation of structural change processes in RA and also, if possible, to document radiological remission or even progression. The REMISSION(PLUS) project also includes the setting up of specialized centers of excellence, which will network to support the implementation and access to the various imaging procedures at hospitals, rheumatology clinics and rheumatology practices nationwide.

Publication types

  • English Abstract

MeSH terms

  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / therapy
  • Arthrography*
  • Documentation
  • Follow-Up Studies
  • Humans
  • Joints / pathology
  • Magnetic Resonance Imaging*
  • Patient Care Team*
  • Remission Induction
  • Synovial Membrane / pathology
  • Synovitis / diagnosis
  • Synovitis / therapy
  • Ultrasonography*