Obesity and weight loss alter serum polyunsaturated lipids in humans

Am J Clin Nutr. 1991 Apr;53(4):831-8. doi: 10.1093/ajcn/53.4.831.

Abstract

Serum omega 6 (n-6) fatty acids were assessed in 12 obese women during an outpatient very-low-calorie diet (VLCD). Ten subjects (S10) achieved a mean weight loss of 17 kg over 3-5 mo (initial weight-for-height 157%). Serum was obtained before (baseline) and monthly during the VLCD and from five of them (S5) after 2-3 mo of weight stability (refed) at 21 kg of loss. At baseline for S10, the serum phospholipid (PL) 20:4 omega 6 was 9.16 wt% and differed from normal (12.81 wt%) by P less than 0.0001, but cholesterol ester (CE) 20:4 omega 6 did not differ from normal. During 3 mo of VLCD, the S10 serum PL and CE 18:2 omega 6 fell (P less than 0.005 and 0.0001, respectively). Serum PL 20:4 omega 6 rose to normal during VLCD months 1-3 (P less than 0.01) while the serum CE 20:4 omega 6 rose above normal (P less than 0.0002). During the VLCD, S5 results paralleled S10. However when refed, S5 PL and CE 18:2 omega 6 and 20:4 omega 6 all reverted to baseline (PL 20:4 omega 6 below normal, P less than 0.001). Serum PL 20:4 omega 6 is low in moderate obesity, corrects to normal during a VLCD, but regresses to the predict abnormality after weight loss.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Arachidonic Acid
  • Arachidonic Acids / blood
  • Cholesterol Esters / blood
  • Diet, Reducing*
  • Fatty Acids, Unsaturated / blood*
  • Female
  • Humans
  • Lipids / blood*
  • Obesity / blood*
  • Obesity / diet therapy
  • Phospholipids / blood
  • Weight Loss*

Substances

  • Arachidonic Acids
  • Cholesterol Esters
  • Fatty Acids, Unsaturated
  • Lipids
  • Phospholipids
  • Arachidonic Acid