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, 206 (1-2), 121-4

Circulating Endotoxin and Systemic Immune Activation in Sporadic Amyotrophic Lateral Sclerosis (sALS)

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Circulating Endotoxin and Systemic Immune Activation in Sporadic Amyotrophic Lateral Sclerosis (sALS)

Rongzhen Zhang et al. J Neuroimmunol.

Abstract

The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.

Figures

Figure 1
Figure 1
Plasma levels of LPS in healthy controls (21 ± 6 pg/m, n = 18), AD (61 ± 42 pg/ml, n = 18), and sALS (43 ± 18 pg/ml, n = 23).
Figure 2
Figure 2
Degree of monocyte HLA-DR expression in healthy controls (Mean CD14DR = 495 ± 136, n = 17), AD (Mean CD14DR = 943 ± 417, n = 17), and sALS (Mean CD14DR = 761 ± 274, n = 23).
Figure 3
Figure 3
Correlations between monocyte activation and plasma LPS levels in healthy controls, AD, and sALS: Significantly positive correlation of the degree of monocyte HLA-DR expression with levels of plasma LPS in both sALS and AD.
Figure 4
Figure 4
Relationship of monocyte IL-10 expression to plasma LPS levels in sALS: Negative correlation of degree of IL-10 expression on CD14 cells with plasma LPS levels in sALS.
Figure 5
Figure 5
Relationship of ALSFRS-R scores to plasma LPS levels in sALS patients. Increased LPS levels was highly significant in patients with moderate impairment (n = 12, p<0.001) compared to healthy controls (n = 18).

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