Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

J Neuroimmunol. 2009 Jan 3;206(1-2):121-4. doi: 10.1016/j.jneuroim.2008.09.017. Epub 2008 Nov 14.


The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / blood
  • Amyotrophic Lateral Sclerosis / blood*
  • Amyotrophic Lateral Sclerosis / immunology*
  • Amyotrophic Lateral Sclerosis / pathology
  • Analysis of Variance
  • Endotoxins / blood*
  • Female
  • Flow Cytometry / methods
  • HLA-DR Antigens / metabolism
  • Humans
  • Interleukin-10 / metabolism
  • Lipopolysaccharides / blood*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Male
  • Middle Aged
  • Monocytes / immunology
  • Monocytes / metabolism


  • Endotoxins
  • HLA-DR Antigens
  • Lipopolysaccharides
  • Interleukin-10