Risk factors for nosocomial rotavirus infection in a paediatric hospital: the potential role for rotavirus vaccine use

Vaccine. 2009 Jan 14;27(3):416-20. doi: 10.1016/j.vaccine.2008.10.074. Epub 2008 Nov 17.

Abstract

To analyze the incidence and risk factors (RF) of nosocomial infection (NI) in a paediatric teaching hospital, a retrospective cohort study was conducted in Salvador, Brazil. The Centres for Disease Control and Prevention definitions were used. The detection of the rotavirus antigen in stool was performed using a rapid latex agglutination test. The study group comprised 2978 admissions that accounted for 32,924 patient-days. The incidence of NI was 8.3/1000 patient-days and 9.2/100 admissions. Of the 274 NI episodes, the most common illness and causative agent were gastroenteritis (125; 45.6%) and rotavirus (59; 21.5%), respectively. The RF for rotavirus NI was young age (10+/-8 months vs. 27+/-33 months; mean difference 17 months, 95% CI 15-20 months, p < 0.001). The temporal distribution of community-acquired and NI rotavirus showed similar trends. The universal use of rotavirus vaccine is a potential tool to control NI among children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Antigens, Viral / analysis
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Cohort Studies
  • Cross Infection / epidemiology*
  • Cross Infection / virology*
  • Feces / chemistry
  • Feces / virology
  • Female
  • Gastroenteritis / epidemiology
  • Gastroenteritis / prevention & control
  • Gastroenteritis / virology
  • Hospitals, Teaching
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Latex Fixation Tests
  • Male
  • Retrospective Studies
  • Risk Factors
  • Rotavirus Infections / epidemiology*
  • Rotavirus Vaccines / immunology

Substances

  • Antigens, Viral
  • Rotavirus Vaccines