Autoimmune and inflammatory disorders and risk of malignant lymphomas--an update

J Intern Med. 2008 Dec;264(6):514-27. doi: 10.1111/j.1365-2796.2008.02029.x.


As specific autoimmune disorders now constitute established risk factors for malignant lymphomas, we describe this association. We review reported risk levels, risk determinants, lymphoma subtypes and biological mechanisms in autoimmunity/inflammation, emphasizing on recent findings. Whilst numerous reports describe average lymphoma risks in large patient groups, there's a recent shift of focus to risk determinants and the role of inflammatory activity. Studies highlight associations with diffuse large B-cell lymphoma, apart from lymphoma development in target organs of inflammation. Future studies of high-risk patient subsets using detailed assessments of autoimmunity/inflammation and lymphoma may give important clues to lymphomagenesis.

Publication types

  • Review

MeSH terms

  • Antigens / immunology
  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / immunology
  • Cytokines / immunology
  • Humans
  • Inflammation / complications*
  • Inflammation / immunology
  • Lymphoma / etiology*
  • Lymphoma / immunology
  • Risk


  • Antigens
  • Cytokines