p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling

Biochimie. 2009 Mar;91(3):320-8. doi: 10.1016/j.biochi.2008.10.010. Epub 2008 Oct 30.


p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains. These protein domains allow various functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of their distinct partners. The p120-RasGAP domain participates in protein-protein interactions with Akt, Aurora or RhoGAP to regulate functions described bellow. Here, we summarize, in angiogenesis and cancer, the various functional roles played by p120-RasGAP domains and their effector partners in downstream signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Catalytic Domain
  • Genes, ras
  • Humans
  • Models, Biological
  • Protein Structure, Tertiary
  • Signal Transduction / genetics
  • p120 GTPase Activating Protein / chemistry
  • p120 GTPase Activating Protein / genetics
  • p120 GTPase Activating Protein / metabolism*
  • ras GTPase-Activating Proteins / chemistry
  • ras GTPase-Activating Proteins / genetics
  • ras GTPase-Activating Proteins / metabolism*
  • ras Proteins / genetics
  • ras Proteins / metabolism*
  • src Homology Domains


  • p120 GTPase Activating Protein
  • ras GTPase-Activating Proteins
  • ras Proteins