Rhomboids: 7 years of a new protease family

Semin Cell Dev Biol. 2009 Apr;20(2):231-9. doi: 10.1016/j.semcdb.2008.10.006. Epub 2008 Oct 17.


Drosophila Rhomboid-1 was discovered to be the first known intramembrane serine protease about 7 years ago. The study of the rhomboid-like family has since blossomed, and the purpose of this review is to take stock of where the field is, and how it may progress in the next few years. Three major themes are the increasing understanding of the biological roles of rhomboids, the detailed information we now have about their function and mechanism, and the promising leads they offer as medical targets.

Publication types

  • Review

MeSH terms

  • Animals
  • ErbB Receptors / classification*
  • Humans
  • Membrane Proteins
  • Mitochondria / chemistry
  • Models, Biological
  • Models, Molecular


  • Membrane Proteins
  • RHBDF1 protein, human
  • ErbB Receptors