The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

Trends Immunol. 2009 Jan;30(1):33-42. doi: 10.1016/ Epub 2008 Nov 18.


This review highlights the emerging roles of the Pellino family of E3 ubiquitin ligases as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. The functional importance of the Pellino family as RING-like-domain-containing proteins with intrinsic ubiquitin E3 ligase activity that can catalyse polyubiquitylation of the key TLR signalling molecule IRAK1 is discussed in detail. The importance of Pellino proteins as novel targets for mediating negative regulation of TLR signalling is also explored. This new knowledge and understanding of Pellino biology begins to fill some long-standing voids in our understanding of TLR signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate / immunology*
  • Interleukin-1 Receptor-Associated Kinases / metabolism*
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / classification
  • Nuclear Proteins / metabolism*
  • Protein Binding
  • Signal Transduction / immunology*
  • Ubiquitin-Protein Ligases / classification
  • Ubiquitin-Protein Ligases / metabolism*


  • Nuclear Proteins
  • Ubiquitin-Protein Ligases
  • Interleukin-1 Receptor-Associated Kinases