Potential effect of sodium bicarbonate-containing dentifrice in controlling enamel erosion in situ

Am J Dent. 2008 Oct;21(5):300-2.


Purpose: To assess, by a crossover 2 x 2 in situ study, the speculated protective role of a sodium bicarbonate-containing toothpaste in controlling erosive lesions.

Methods: Bovine enamel slabs were sterilized, and submitted to baseline Knoop microhardness measurements. After a 3-day lead-in period, 14 volunteers wore palatal acrylic appliances containing six enamel slabs (three on each side), for 4 consecutive days. On the first day, appliances with contained specimens were placed in the oral cavity to allow salivary pellicle formation. On the subsequent days, half of the enamel slabs were immersed extraorally in a lemonade-like soft drink for 90 seconds, twice daily. On both of these occasions, the appliance was dipped in toothpaste slurry of either a sodium bicarbonate-containing toothpaste or a regular counterpart for 60 seconds. Following a 3-day washout period, a new set of enamel slabs were mounted and the volunteers started the second period using the alternate dentifrice.

Results: ANOVA (alpha = 0.05) showed no statistically significant difference between enamel treated with regular and sodium bicarbonate-based dentifrices, regardless of whether specimens were eroded or not (P = 0.8430). Acid-challenged specimens revealed lower microhardness values than uneroded samples.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Animals
  • Cattle
  • Cross-Over Studies
  • Dental Enamel
  • Dentifrices / chemistry
  • Dentifrices / therapeutic use*
  • Double-Blind Method
  • Female
  • Hardness
  • Humans
  • Male
  • Sodium Bicarbonate / therapeutic use*
  • Tooth Erosion / prevention & control*
  • Young Adult


  • Dentifrices
  • Sodium Bicarbonate