The aqueous and methanolic extract of a preparation; Diabo-SS (100 mg/kg b.wt) was administered to streptozotocin-induced diabetic animals. The aqueous Diabo-SS extract showed significantly (P < .001) higher anti-diabetic activity than the methanolic extract. Continuous administration of the aqueous extract of Diabo-SS reduced the plasma glucose level by 40% on 60th day. The tail flick latency (TFL) and gastric transit percentages were significantly higher in diabetic controls versus normal control animals.