Improved 3D phase contrast MRI with off-resonance corrected dual echo VIPR

Magn Reson Med. 2008 Dec;60(6):1329-36. doi: 10.1002/mrm.21763.


Phase contrast (PC) magnetic resonance imaging with a three-dimensional, radially undersampled acquisition allows for the acquisition of high resolution angiograms and velocimetry in dramatically reduced scan times. However, such an acquisition is sensitive to blurring and artifacts from off-resonance and trajectory errors. A dual-echo trajectory is proposed with a novel trajectory calibration from prescan data coupled with a multi-frequency reconstruction to correct for these errors. Comparisons of phantom data and in vivo results from volunteer, and patients with arteriovenous malformations patients are presented with and without these corrections and show significant improvement of image quality when both corrections are applied. The results demonstrate significantly improved visualization of vessels, allowing for highly accelerated PC acquisitions without sacrifice in image quality.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms*
  • Artifacts*
  • Brain / anatomy & histology*
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Magnetic Resonance Imaging / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity