The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate

Clin Perinatol. 2008 Dec;35(4):777-92, vii. doi: 10.1016/j.clp.2008.07.014.


Intraventricular hemorrhage (IVH) occurs in 20% to 25% of very low birthweight preterm neonates and may be associated with significant sequelae. Infants who have IVH are at risk for posthemorrhagic hydrocephalus and periventricular leukomalacia; as many as 75% of those who have parenchymal involvement of hemorrhage suffer significant neurodevelopmental disability. Because of the prevalence of IVH and the medical and societal impact of this disease, many postnatal pharmacologic prevention strategies have been explored. Randomized clinical prevention trials should provide long-term neurodevelopmental follow-up to assess the impact of preterm birth, injury, and pharmacologic intervention on the developing brain.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / diagnosis*
  • Cerebral Hemorrhage / physiopathology
  • Cerebral Hemorrhage / prevention & control*
  • Cerebral Ventricles / blood supply*
  • Coagulants / therapeutic use
  • Cyclooxygenase Inhibitors / therapeutic use
  • Factor VIIa / therapeutic use
  • Humans
  • Ibuprofen / therapeutic use
  • Indomethacin / therapeutic use
  • Infant, Newborn
  • Infant, Premature*
  • Phenobarbital / therapeutic use


  • Coagulants
  • Cyclooxygenase Inhibitors
  • Factor VIIa
  • Ibuprofen
  • Indomethacin
  • Phenobarbital