Evaluation of mifepristone as a once a month contraceptive pill

Am J Obstet Gynecol. 2009 May;200(5):e27-9. doi: 10.1016/j.ajog.2008.09.005. Epub 2008 Nov 21.


Objective: The purpose of this study was to assess the efficacy and safety of mifepristone as a contraceptive pill.

Study design: A prospective case-control study was conducted in a tertiary care center of North India. The study group (n = 86) was given 200-mg mifepristone tablets on the 16th day of the menstrual cycle. The control group (n = 92) received combined oral contraceptive (COC) as per protocol. Subjects were followed for drug compliance, satisfaction, side effects, and failure.

Results: Acceptability of mifepristone was significantly higher in educated population (P < .001), with fewer side effects (P = .001), good satisfaction (P < .001), and higher compliance rate (P = .05). The oral contraceptive pill group had higher adverse biochemical parameters.

Conclusion: Mifepristone can be used as a monthly contraceptive pill effectively.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Contraception / methods*
  • Contraceptives, Oral, Synthetic / administration & dosage*
  • Contraceptives, Oral, Synthetic / adverse effects
  • Female
  • Follow-Up Studies
  • Humans
  • India
  • Menstrual Cycle
  • Mifepristone / administration & dosage*
  • Mifepristone / adverse effects
  • Patient Satisfaction*
  • Prospective Studies
  • Young Adult


  • Contraceptives, Oral, Synthetic
  • Mifepristone