Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

Cardiovasc Pathol. Mar-Apr 2010;19(2):e33-6. doi: 10.1016/j.carpath.2008.09.004. Epub 2008 Nov 21.

Abstract

A 41-year-old male with cardiomyopathy from an inherited beta myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, CD / metabolism
  • Biomarkers / metabolism
  • Cardiac Myosins / genetics
  • Cardiac Myosins / metabolism
  • Cardiomyopathy, Hypertrophic, Familial / genetics
  • Cardiomyopathy, Hypertrophic, Familial / pathology
  • Cardiomyopathy, Hypertrophic, Familial / surgery*
  • Fatal Outcome
  • Fibrosis / metabolism
  • Fibrosis / pathology
  • Humans
  • Male
  • Mutation / genetics
  • Myocardium / metabolism
  • Myocardium / pathology
  • Myosin Heavy Chains / genetics
  • Myosin Heavy Chains / metabolism
  • Peripheral Blood Stem Cell Transplantation / adverse effects*
  • Postoperative Complications / etiology*
  • Postoperative Complications / pathology
  • Transplantation, Autologous
  • Ventricular Fibrillation / etiology*
  • Ventricular Fibrillation / pathology

Substances

  • Antigens, CD
  • Biomarkers
  • MYH7 protein, human
  • Cardiac Myosins
  • Myosin Heavy Chains