Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass

Perfusion. 2008 May;23(3):165-71. doi: 10.1177/0267659108098215.

Abstract

The glycocalyx covering the endothelium is shed during ischemia and reperfusion. The shedding is accompanied by increased levels of the glycocalyx component syndecan-1 in the circulation. Our aim was to compare plasma levels of syndecan-1 in patients undergoing coronary artery bypass grafting (CABG), with or without the use of cardiopulmonary bypass (CPB). Syndecan-1 plasma concentrations were measured in patients undergoing CABG on-pump (nA =A 22) or off-pump (nA =A 22). The syndecan-1 concentration increased significantly from 29.5 +/- 4.6 ng/mL at baseline to 98.7 +/- 9.8 ng/mL (pA <A 0.01) after the start of CPB or 30 minutes after the induction of anesthesia in the off-pump group. There were no significant differences in peak syndecan-1 plasma concentrations between on-pump and off-pump patients. Plasma levels of syndecan-1 increased significantly during CABG, with or without the use of CPB. There were no significant differences in syndecan-1 concentrations in the two groups.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Cardiopulmonary Bypass / adverse effects*
  • Cohort Studies
  • Coronary Artery Bypass, Off-Pump / adverse effects*
  • Cytokines / blood
  • Female
  • Glycocalyx
  • Heart Diseases / blood
  • Heart Diseases / surgery*
  • Humans
  • Inflammation / blood*
  • Inflammation / etiology
  • Male
  • Middle Aged
  • Postoperative Complications / blood*
  • Risk Factors
  • Syndecan-1 / blood*

Substances

  • Cytokines
  • Syndecan-1