Individuals who have suffered polytrauma injuries must often contend with a complex constellation of physical, psychological, and psychosocial factors. These variables must be understood and addressed by rehabilitation specialists in order to optimize employment outcomes and overall quality of life for persons who have incurred these injuries. This article provides an abridged review of the current empirical data concerning the relationship between polytrauma and employment outcomes, with a focus on traumatic brain injury (TBI). In addition, Bordin's [4] working alliance model is recommended as a framework for strengthening the relationship between rehabilitation professionals and persons with TBI, thereby optimizing their employment outcomes.