Reflecting on 25 years with MYC

Nat Rev Cancer. 2008 Dec;8(12):976-90. doi: 10.1038/nrc2231.


Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is astonishing how each incremental insight into MYC regulation and function has also had an impact on numerous biological disciplines, including our understanding of molecular oncogenesis in general. Here we chronicle the major advances in our understanding of MYC biology, and peer into the future of MYC research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Genes, myc*
  • Humans
  • Mice
  • Neoplasms / genetics*
  • Oncogenes
  • Proto-Oncogene Proteins c-myc / genetics
  • Translocation, Genetic / genetics
  • Viruses / genetics


  • Proto-Oncogene Proteins c-myc