Beyond HPV: oncomirs as new players in cervical cancer

FEBS Lett. 2008 Dec 24;582(30):4113-6. doi: 10.1016/j.febslet.2008.11.011. Epub 2008 Nov 24.


MicroRNAs (miRNAs) are a recently discovered family of 18-24 nucleotide non-coding RNAs that can negatively regulate target mRNAs. All studied multicellular eukaryotes utilize miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. This review discusses the various cancer-relevant miRNAs (oncomirs) especially in cervical tumorigenesis and the potential role of oncomirs as therapeutic agents and targets for the treatment of cervical cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma / drug therapy
  • Carcinoma / genetics*
  • Carcinoma / therapy
  • Cell Transformation, Neoplastic / genetics*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • MicroRNAs / classification
  • MicroRNAs / drug effects
  • MicroRNAs / metabolism*
  • Uterine Cervical Neoplasms / drug therapy
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / therapy


  • MicroRNAs